Disclosed herein are solutions to these and other problems in the art. ![]() In view of the foregoing, innovative approaches to address issues with existing sequencing technologies are needed. Due to the read lengths of current NGS platforms, ranging in length from 35 to 300 base pairs, nucleic acid sequencing technologies may struggle with accurately mapping sequences having large structural variations, e.g., inversions and translocations, tandem repeat regions, distinguishing clinically relevant genes from pseudogenes, and haplotype reconstructions. Certain NGS sequencing methodologies make use of simultaneously sequencing millions of fragments of nucleic acids, resulting in a 50,000-fold drop in the costs associated with sequencing since its inception. BACKGROUNDĪ number of next-generation sequencing (NGS) platforms are available for the high-throughput, massively parallel sequencing of nucleic acids. The instant application contains a Sequence Listing which has been submitted electronically in ASCII format and is hereby incorporated by reference in its entirety. ![]() 31, 2019, which is incorporated herein by reference in its entirety and for all purposes. This application claims the benefit of U.S.
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